反应详情

温度

50 °C

Dissolved N-(4-chloromethyl-thiazol-2-yl)-acetamide (250 mg, 1.31 mmol) in 5 mL of THF. To this was added Na2CO3 (250 mg). Bubbled dimethyl amine in for 15 min. Sealed the flask and heated at 50° C. for 2 h. LC-MS analysis indicated the desired adduct. Filtered the mixture through diatomaceous earth and washed plug with 2×10 mL of THF. Concentrated to dryness to give 274 mg of N-(4-dimethylaminomethyl-thiazol-2-yl)-acetamide.

1. customin for 15 min
2. customSealed the flask
3. filtrationFiltered the mixture through diatomaceous earth
4. washwashed plug with 2×10 mL of THF
5. concentrationConcentrated to dryness