Acetone → HCID 22467910, compound

HRID 418355Notes

Reaction equation

HRID 418355 reaction equation
[Cl:1][CH2:2][C:3]([CH2:5]Cl)=O.[NH2:7][C:8]([NH2:10])=[S:9].CC(C)=[O:13]>>[ClH:1].[NH2:7][C:8]1[S:9][CH:5]=[C:3]([CH2:2][OH:13])[N:10]=1

Participants

4

Reactant 3

HCID 180Acetone2×HCID 107931,3-DichloroacetoneHCID 2723790Thiourea

Product 1

HCID 22467910HCID 22467910, compound

Procedure

A solution of 1,3-dichloroacetone (917 mg, 7.23 mmol) in acetone (6 mL) was added a solution of thiourea (550 mg, 7.23 mmol) in acetone (30 mL) at a fairly fast speed. The mixture was stirred at room temperature overnight. The formed solid was filtered and the filtrate was concentrated to give 524 mg of (2-amino-thiazol-4-yl)-methanol monohydrochloride as colorless oil.

Workup

  1. filtrationThe formed solid was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-4d5ad3778dfd4039bcb41c0f107cbe1f
Source dataset
uspto-grants-2012_01
Patent number
US08093266B2

Reaction notes

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