Hydrochloric Acid → HCID 59627748, compound

HRID 418392Notes

Reaction equation

HRID 418392 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[CH:8]=[C:9]([I:11])[CH:10]=1)=[O:4].[OH-].[Na+].Cl>CO>[I:11][C:9]1[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[C:7]([C:12]2[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 578515885-Iodo-4'-methyl-biphenyl-3-carboxylic acid methyl ester

Product 1

HCID 59627748HCID 59627748, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-Iodo-4′-methyl-biphenyl-3-carboxylic acid methyl ester (280 mg, 0.8 mmol) was added to a mixture of methanol (4 mL) and 2M aqueous NaOH (2 mL). The mixture was stirred for 48 hours at room temperature, then neutralized by addition of 1M aqueous HCl. Solvent was removed under reduced pressure and the mixture was coevaporated twice with toluene to give crude 5-iodo-4′-methyl-biphenyl-3-carboxylic acid, which was used directly in the next step.

Workup

  1. customSolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-20903571eb09456ea21cc1894cba1589
Source dataset
uspto-grants-2012_01
Patent number
US08093275B2

Reaction notes

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