HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 418424Generated: October 27, 2026
2,5-Dimethyl-1H-indole → 8-Methyl-(2,5-dimethyl-1H-indol-3-yl)quinoline
https://huagongshe.com/reaction/418424
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,5-Dimethyl-1H-indole | HCID 70965 | — |
| Reactant | 4-Chloro-8-methylquinoline | HCID 12326335 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 8-Methyl-(2,5-dimethyl-1H-indol-3-yl)quinoline | HCID 18729479 | 99.7% |
Reaction Steps
2,5-Dimethylindole (290 mg) and 8-methyl-4-chloroquinoline (360 mg) were suspended in N-methylpyrolidinone (0.5 ml), and maintained under a nitrogen atmosphere. The reaction was heated to 140° C. with stirring for 45 minutes. On cooling a deep red precipitate formed, the mixture was diluted with diethylether and the solid collected by filtration, and dried to give the sub-title compound (570 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08093278B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-ae91cbb6e53f482bb788d4d9733ac7db |
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| Source note | uspto-grants-2012_01 |
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