Sodium Hydroxide → HCID 10046404, compound

HRID 418429Notes

Reaction equation

HRID 418429 reaction equation
[CH3:1][C:2]1[N:3]([CH2:26][C:27]([O:29]CC)=[O:28])[C:4]2[C:9]([C:10]=1[C:11]1[C:20]3[C:15](=[C:16]([C:21]([F:24])([F:23])[F:22])[CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][CH:12]=1)=[CH:8][C:7]([CH3:25])=[CH:6][CH:5]=2.[OH-].[Na+]>C1COCC1.CO>[CH3:1][C:2]1[N:3]([CH2:26][C:27]([OH:29])=[O:28])[C:4]2[C:9]([C:10]=1[C:11]1[C:20]3[C:15](=[C:16]([C:21]([F:22])([F:23])[F:24])[CH:17]=[CH:18][CH:19]=3)[N:14]=[CH:13][CH:12]=1)=[CH:8][C:7]([CH3:25])=[CH:6][CH:5]=2

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 66651780HCID 66651780, compound

Product 1

HCID 10046404HCID 10046404, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of product from step b) (1.46 g) and 1 M sodium hydroxide (3.42 ml) in THF (20 ml) and methanol (2 ml) was stirred for 16 hours. The solvent was removed in vacuo and the residue was dissolved in water (20 ml) and washed with dichloromethane. 1M HCl (3.4 ml) was added slowly to the stirred solution. The precipitate was collected and dried to give the title compound (1.23 g. M.p. 145° C.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in water (20 ml)
  3. washwashed with dichloromethane
  4. addition1M HCl (3.4 ml) was added slowly to the stirred solution
  5. customThe precipitate was collected
  6. customdried

Sources & evidence

ORD record
ord-6c4e8d9c8e0f4ff2bcbe38a9879f3d84
Source dataset
uspto-grants-2012_01
Patent number
US08093278B2

Reaction notes

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