HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(2,5-dimethyl-1H-indol-3-yl)-benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 2,5-Dimethyl-1H-indole | HCID 70965 | — |
| Reactant | 2-Chloro-1,3-oxazole | HCID 13371074 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(2,5-dimethyl-1H-indol-3-yl)-benzoxazole | HCID 68457518 | — |
Reaction Steps
2,5-dimethyl indole (0.3 g), 2-chlorooxazole (0.47 g) and NMP (2 ml) were heated in a microwave at 100 watts for 20 min at 160° C. Water ane EtOAc were added and separated, the aqueous phase was re-extracted with EtOAc (×4). The combined organic extracts were dried (MgSO4) and concentrated in vacuo. The precipitate was triturated with EtOAc then recrystallised from methanol to give the title compound (0.19 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093278B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-1c7720cdc9f248b9ade995052acb0d4c |
| Source note | uspto-grants-2012_01 |