反应详情

2,5-dimethyl indole (0.3 g), 2-chlorooxazole (0.47 g) and NMP (2 ml) were heated in a microwave at 100 watts for 20 min at 160° C. Water ane EtOAc were added and separated, the aqueous phase was re-extracted with EtOAc (×4). The combined organic extracts were dried (MgSO4) and concentrated in vacuo. The precipitate was triturated with EtOAc then recrystallised from methanol to give the title compound (0.19 g).

1. customseparated
2. extractionthe aqueous phase was re-extracted with EtOAc (×4)
3. dry with materialThe combined organic extracts were dried (MgSO4)
4. concentrationconcentrated in vacuo
5. customThe precipitate was triturated with EtOAc
6. customthen recrystallised from methanol