反应详情

温度

80 °C

In 110 g of dimethyl sulfoxide were dispersed 21.6 g (0.15 mol) of 1-naphthol, 27.4 g (0.1 mol) of 2-(2-methoxy-ethoxy)ethyl 4-toluenesulfonate, and 20.7 g (0.15 mol) of potassium carbonate. The dispersion was heated and stirred at 80° C. for 3 hours. After cooling, the solution was combined with 200 g of water and 200 g of toluene, from which an organic layer was separated. It was washed 2 times with 50 g of water, 5 times with 2.5 wt % sodium hydroxide aqueous solution and then 4 times with 100 g of water. The organic layer was concentrated, obtaining 21 g of oily matter. On vacuum distillation (120° C./0.06 Torr), 18.6 g of the target compound was recovered (yield 75%).

1. temperatureThe dispersion was heated
2. temperatureAfter cooling
3. customwas separated
4. washIt was washed 2 times with 50 g of water, 5 times with 2.5 wt % sodium hydroxide aqueous solution
5. concentrationThe organic layer was concentrated
6. customobtaining 21 g of oily matter
7. distillationOn vacuum distillation (120° C./0.06 Torr), 18.6 g of the target compound
8. customwas recovered (yield 75%)