Trimethyl orthoformate → 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

HRID 418450Notes

Reaction equation

HRID 418450 reaction equation
[CH3:1][C:2]1([CH3:10])[O:7][C:6](=[O:8])[CH2:5][C:4](=[O:9])[O:3]1.[CH3:11][O:12][CH:13](OC)OC>>[CH3:11][O:12][CH:13]=[C:5]1[C:6](=[O:8])[O:7][C:2]([CH3:10])([CH3:1])[O:3][C:4]1=[O:9]

Participants

3

Reactant 2

HCID 9005Trimethyl orthoformateHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 1521115-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Procedure

2,2-Dimethyl-1,3-dioxane-4,6-dione (100 g) was heated in trimethylorthoformate (500 ml) at 100° C. for 2 h. The solution was evaporated under reduced pressure to give an oil. The oil was triturated with 1:1 isohexane/diethyl ether (400 ml) and the solid was filtrated and dried in vacuo to give the sub-title compound (99.8 g).

Workup

  1. customThe solution was evaporated under reduced pressure
  2. customto give an oil
  3. customThe oil was triturated with 1:1 isohexane/diethyl ether (400 ml)
  4. filtrationthe solid was filtrated
  5. customdried in vacuo

Sources & evidence

ORD record
ord-6be1fd51557d4d7188eb20749da31599
Source dataset
uspto-grants-2012_01
Patent number
US08093278B2

Reaction notes

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