反应详情

2-difluoromethoxyaniline (7.63 g) and the product from step a) were stirred in acetonitrile (100 ml) overnight. The solvent was removed by evaporation and the solid triturated with 4:1 isohexane/diethyl ether (200 ml) before filtering to give a light green solid. The solid was added portionwise to refluxing diphenylether (120 ml) and continued heating for a further 10 minutes before cooling. The solution was poured into isohexane (600 ml) and the solid filtered off to give the title compound (12.0 g).

1. customThe solvent was removed by evaporation
2. customthe solid triturated with 4:1 isohexane/diethyl ether (200 ml)
3. filtrationbefore filtering
4. customto give a light green solid
5. additionThe solid was added portionwise
6. temperaturecontinued heating for a further 10 minutes
7. temperaturebefore cooling
8. filtrationthe solid filtered off