Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 5-Chloro-2-methyl-[3,5'-bi-1-indole]-1-acetic acid, ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Tri-o-tolylphosphine | HCID 80271 | — |
| 반응물 | 5-Indolylboronic acid | HCID 2734361 | — |
| 반응물 | 5-Chloro-2-methyl-3-(8-quinolinyl)-1H-indole-1-acetic acid | HCID 10383271 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Chloro-2-methyl-[3,5'-bi-1-indole]-1-acetic acid, ethyl ester | HCID 86761485 | — |
반응 단계
The product of Example 51 part b (200 mg), 5-indole boronic acid (100 mg), potassium carbonate (0.73 g), acetone (6 ml), water (3 ml), palladium acetate (12 mg) and tri(o-tolyl) phosphine (30 mg) were heated at 90° C. for 4 hours. The reaction mixture was concentrated in vacuo, purified by silica chromatography eluting with hexane:EtOAc (7:3) to give the sub-title compound (140 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093278B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-30f7720dcc3e4848865d428ed4cda11c |
| 출처 메모 | uspto-grants-2012_01 |