反应详情

The product of Example 51 part b (200 mg), 5-indole boronic acid (100 mg), potassium carbonate (0.73 g), acetone (6 ml), water (3 ml), palladium acetate (12 mg) and tri(o-tolyl) phosphine (30 mg) were heated at 90° C. for 4 hours. The reaction mixture was concentrated in vacuo, purified by silica chromatography eluting with hexane:EtOAc (7:3) to give the sub-title compound (140 mg).

1. concentrationThe reaction mixture was concentrated in vacuo
2. custompurified by silica chromatography
3. washeluting with hexane:EtOAc (7:3)