反应详情

(E)-Methyl 2-(2-(dimethylamino) vinyl)-3-nitrobenzoate was dissolved in ethyl acetate (200 mL), and silica gel (200 g) was added. The resulting suspension was stirred at room temperature for 1 h. The ethyl acetate solution was filtered off. Silica gel was washed with ethyl acetate (2×150 mL) and the combined organics were evaporated and dried under reduced pressure to yield 5-nitro-1H-isochromen-1-one (4.0 g, 21.0 mmol, 82% after two steps) as a brown solid.

1. additionsilica gel (200 g) was added
2. filtrationThe ethyl acetate solution was filtered off
3. washSilica gel was washed with ethyl acetate (2×150 mL)
4. customthe combined organics were evaporated
5. customdried under reduced pressure