反应详情

温度

55 °C

To a solution of 6-chloro-5-nitro-1H-isochromen-1-one (950 mg, 0.0042 mol) in methanol (30 mL, 0.7 mol) was added triethylamine (0.64 mL, 0.0046 mol) and (R)-2-aminopropanamide hydrochloride (0.58 g, 0.0046 mol). The reaction was heated to 55° C. overnight and the solvent was removed under reduced pressure. The residue was purified by flash chromatography to afford the product as light yellow solid.

1. customthe solvent was removed under reduced pressure
2. customThe residue was purified by flash chromatography