反应详情

A round bottom flask was charged with 2-(2-(2-acetoxyethyl)-5-(2-(2-fluoro-3-(trifluoromethyl)phenyl)acetamido)-1-oxo-1,2-dihydroisoquinolin-6-ylamino)ethyl acetate (120 mg, 0.00022 mol), potassium carbonate (45 mg, 0.00033 mol) and methanol (3 mL, 0.07 mol) and 2 drops of water. The reaction was stirred at room temperature for 30 minutes, filtered over sodium sulfate, and the solvent removed under reduced pressure. The residue was purified by flash chromatography to afford the product as a white solid.

1. filtrationfiltered over sodium sulfate
2. customthe solvent removed under reduced pressure
3. customThe residue was purified by flash chromatography