HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 25014109, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 59845737 | HCID 59845737 | — |
| Product | HCID 25014109 | HCID 25014109 | — |
Reaction Steps
(2R)-2-(6-Chloro-5-((6-hydroxyspiro[2.5]octan-6-yl)methylcarbamoyl)-1-oxoisoquinolin-2(1H)-yl)propyl acetate (130 mg, 0.00029 mol) and potassium carbonate (140 mg, 0.0010 mol) were stirred in methanol (6 mL, 0.1 mol) at room temperature for 1 hour, concentrated, and purified by reverse phase preparative HPLC to afford the desired product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093265B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-69f644d557b041469867f0a4403fafad |
| Source note | uspto-grants-2012_01 |