Methanol → HCID 25014109, compound

HRID 418544Notes

Reaction equation

HRID 418544 reaction equation
C([O:4][CH2:5][C@H:6]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Cl:31])[C:14]=2[C:18](=[O:30])[NH:19][CH2:20][C:21]2([OH:29])[CH2:28][CH2:27][C:24]3([CH2:26][CH2:25]3)[CH2:23][CH2:22]2)[C:9]1=[O:32])[CH3:7])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>>[Cl:31][C:13]1[CH:12]=[CH:11][C:10]2[C:9](=[O:32])[N:8]([C@H:6]([CH3:7])[CH2:5][OH:4])[CH:17]=[CH:16][C:15]=2[C:14]=1[C:18]([NH:19][CH2:20][C:21]1([OH:29])[CH2:22][CH2:23][C:24]2([CH2:25][CH2:26]2)[CH2:27][CH2:28]1)=[O:30]

Participants

4

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 59845737HCID 59845737, compound

Product 1

HCID 25014109HCID 25014109, compound

Procedure

(2R)-2-(6-Chloro-5-((6-hydroxyspiro[2.5]octan-6-yl)methylcarbamoyl)-1-oxoisoquinolin-2(1H)-yl)propyl acetate (130 mg, 0.00029 mol) and potassium carbonate (140 mg, 0.0010 mol) were stirred in methanol (6 mL, 0.1 mol) at room temperature for 1 hour, concentrated, and purified by reverse phase preparative HPLC to afford the desired product as a white solid.

Workup

  1. concentrationconcentrated
  2. custompurified by reverse phase preparative HPLC

Sources & evidence

ORD record
ord-69f644d557b041469867f0a4403fafad
Source dataset
uspto-grants-2012_01
Patent number
US08093265B2

Reaction notes

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