Trifluoroacetic acid → HCID 16041776, compound

HRID 418627Notes

Reaction equation

HRID 418627 reaction equation
[F:1][C:2]1[CH:33]=[C:32]([NH:34][C:35](=[O:48])[CH2:36][C:37]([NH:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=2[O:46][CH3:47])=[O:38])[CH:31]=[CH:30][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]3[N:15]=[CH:16][N:17]([CH2:19][CH2:20][N:21](C)[C:22](=O)OC(C)(C)C)[CH:18]=3)[S:13][C:6]=12.C(O)(C(F)(F)F)=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:33]=[C:32]([NH:34][C:35](=[O:48])[CH2:36][C:37]([NH:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=2[O:46][CH3:47])=[O:38])[CH:31]=[CH:30][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]3[N:15]=[CH:16][N:17]([CH2:19][CH2:20][NH:21][CH3:22])[CH:18]=3)[S:13][C:6]=12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58790350HCID 58790350, compound

Product 1

HCID 16041776HCID 16041776, compoundYield 177.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 101 (31 mg, 0.046 mmol) in toluene (1 ml) was added TFA (excess) and the reaction mixture was stirred at RT for an hour. The solvents were removed and the title compound 96 (47 mg, 100% yield) was obtained after trituration of the resultant solid. MS (m/z): 575.1 (M+H).

Workup

  1. customThe solvents were removed

Sources & evidence

ORD record
ord-667ec7b72b034c32934f8c2e5fd62923
Source dataset
uspto-grants-2012_01
Patent number
US08093264B2

Reaction notes

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