2-Fluoro-4-nitrophenol → 1-(1-Ethyl-4-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1H-imidazol-2-yl)-N,N-dimethylmethanamine

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoro-4-nitrophenol	HCID 9825	—
Reactant	1-(4-(7-Chlorothieno[3,2-b]pyridin-2-yl)-1-ethyl-1H-imidazol-2-yl)-N,N-dimethylmethanamine	HCID 58790245	—
Reactant	2-(1-Ethyl-1H-imidazol-4-yl)-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine	HCID 66649032	—
Product	1-(1-Ethyl-4-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1H-imidazol-2-yl)-N,N-dimethylmethanamine	HCID 58790400	48%

Reaction Steps

Starting from the chloride 112 and 2-fluoro-4-nitrophenol and following the same procedure as described above for the synthesis of compound 14 (scheme 4), title compound 113 was obtained as yellow solid in 48% yield. MS (m/z): 442.1 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093264B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-20210774202d444581a8c3f69cfa1794
Source note	uspto-grants-2012_01