反应详情

温度

60 °C

To a suspension of the chloride 148 (3.8 g, 8.42 mmol) in dimethylformamide (42 mL) was added dimethylamine (8.4 mL, 16.84 mmol) and the reaction mixture was heated to 60° C. After few hours the reaction was complete and the dimethylformamide was evaporated. The residue was triturated with ethyl acetate, collected by filtration, washed with ethyl acetate and dried to afford title compound 149 as a yellow solid (1.71 g, 48% yield). MS (m/z): 424.0 (M+H).

1. waitAfter few hours the reaction was complete
2. customthe dimethylformamide was evaporated
3. customThe residue was triturated with ethyl acetate
4. filtrationcollected by filtration
5. washwashed with ethyl acetate
6. customdried