1-(3-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)-N,N-dimethylmethanamine → 4-(2-(3-((Dimethylamino)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluoroaniline

Participants

Role	Name	HCID	Charge
Reactant	1-(3-(7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)phenyl)-N,N-dimethylmethanamine	HCID 58790281	—
Reactant	(7-(4-Amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone	HCID 59424653	—
Product	4-(2-(3-((Dimethylamino)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluoroaniline	HCID 58790102	44%

Reaction Steps

Starting from the compound 149 and following the same procedure as described above for the synthesis of compound 23 (scheme 6), title compound 150 was obtained in 44% yield MS (m/z): 394.0 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093264B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-428ba5e088ff4a46a0779d9a0f472106
Source note	uspto-grants-2012_01