P-Anisidine → 3-(4-Methoxyanilino)-3-oxopropanoic acid

HRID 418654Notes

Reaction equation

HRID 418654 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.COC1C=CC=CC=1N[C:19](=[O:24])[CH2:20][C:21]([OH:23])=[O:22]>>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH:7][C:19](=[O:24])[CH2:20][C:21]([OH:23])=[O:22])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 12664594N-(2-Methoxy-phenyl)-malonamic acid

Product 1

HCID 116585393-(4-Methoxyanilino)-3-oxopropanoic acidYield 56%

Procedure

Starting from 4-methoxyaniline and following the procedure described above for the synthesis of compound 27 (example 8, scheme 8), title compound 157 was obtained in 56% yield. MS (m/z): 210.0 (M+H).

Sources & evidence

ORD record
ord-f12416f22093495b8f4499dc47dbfc6d
Source dataset
uspto-grants-2012_01
Patent number
US08093264B2

Reaction notes

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