2-Methoxyaniline → 1-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acid

HRID 418658Notes

Reaction equation

HRID 418658 reaction equation
[C:1]1([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][O:17]C1C=CC=CC=1N>>[CH3:16][O:17][C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][C:1]=1[NH:7][C:8]([C:10]1([C:13]([OH:15])=[O:14])[CH2:11][CH2:12]1)=[O:9]

Participants

3

Reactant 2

HCID 70002-MethoxyanilineHCID 190968711-(Phenylcarbamoyl)cyclopropanecarboxylic acid

Product 1

HCID 550353091-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acidYield 44%

Procedure

Following the procedure described above for the synthesis of compound 161 (Scheme 45), but replacing aniline for 2-methoxyaniline, title compound 172 was obtained in 44% yield. M/S (m/z): 236.0 (M+H).

Sources & evidence

ORD record
ord-15ab14e4b7e44732b59a7694cef05636
Source dataset
uspto-grants-2012_01
Patent number
US08093264B2

Reaction notes

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