反应详情

To a solution of 2-(4-carboxybenzyl)-3-isopropylmaleic acid dimethyl ester (7.8 mg, 0.024 mmol) in tetrahydrofuran (400 μL) were added a 0.5 M ammonia-dioxane solution (600 μL) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (14.8 mg, 0.0535 mmol), and the mixture was stirred at room temperature for 4 h. The reaction mixture was directly concentrated under reduced pressure and the residue thus obtained was subjected to silica gel column chromatography (hexane-ethyl acetate 1:4) to give 7.0 mg of the title compound as a solid (yield: 90%).

1. concentrationThe reaction mixture was directly concentrated under reduced pressure
2. customthe residue thus obtained