HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane | HCID 16099239 | — |
| Reactant | 1-Phenyl-1H-indazol-4-amine hydrochloride | HCID 66648452 | — |
| Catalyst | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol | HCID 57615944 | — |
Reaction Steps
Prepared similarly to Example 1 from racemic 2-{2-[5-fluoro-2-(methyloxy)phenyl]-2-methylpropyl}-2-(trifluoromethyl)oxirane and 1-phenyl-1H-indazol-4-amine hydrochloride (as the free base, Intermediate 8) except that ca. 5 drops of NMP were added to the reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093281B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-6c31247e38aa4dc0ae67faaf53f9462b |
| Source note | uspto-grants-2012_01 |