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HRID418794

反应详情

EQUATION

反应方程式

HRID 418794 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(F)cc1C(C)(C)CC1(C(F)(F)F)CO1
HCID16099239

未命名化合物

结构：Cl.Nc1cccc2c1cnn2-c1ccccc1
HCID66648452

未命名化合物

2 次

PRODUCTS

生成物

1
结构：COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cccc2c1cnn2-c1ccccc1)C(F)(F)F
HCID57615944

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
催化剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

Prepared similarly to Example 1 from racemic 2-{2-[5-fluoro-2-(methyloxy)phenyl]-2-methylpropyl}-2-(trifluoromethyl)oxirane and 1-phenyl-1H-indazol-4-amine hydrochloride (as the free base, Intermediate 8) except that ca. 5 drops of NMP were added to the reaction mixture.

WORKUP

后处理

  1. additionwere added to the reaction mixture