HRID418796

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57615935

未命名化合物

2 次

HCID57775518

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cccc(-n2ncc3c(NCC(O)(CC(C)(C)c4cccc5c4OCC5)C(F)(F)F)cccc32)c1

HCID57615954

未命名化合物

PROCEDURE

实验过程

Prepared similarly to Example 1 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and ethyl 3-(4-amino-1H-indazol-1-yl)benzoate (Intermediate 6).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-12a0db22f6354e5fbec43fc61714b8a3
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08093281B2
来源说明: uspto-grants-2012_01

反应 SMILES

[CH3:1][C:2]([C:12]1[C:20]2[O:19][CH2:18][CH2:17][C:16]=2[CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH2:3][C:4]1([C:7]([F:10])([F:9])[F:8])[CH2:6][O:5]1.[NH2:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:23]=1[CH:24]=[N:25][N:26]2[C:31]1[CH:32]=[C:33]([CH:39]=[CH:40][CH:41]=1)[C:34]([O:36][CH2:37][CH3:38])=[O:35]>>[O:19]1[C:20]2[C:12]([C:2]([CH3:11])([CH3:1])[CH2:3][C:4]([OH:5])([C:7]([F:8])([F:10])[F:9])[CH2:6][NH:21][C:22]3[CH:30]=[CH:29][CH:28]=[C:27]4[C:23]=3[CH:24]=[N:25][N:26]4[C:31]3[CH:32]=[C:33]([CH:39]=[CH:40][CH:41]=3)[C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:13][CH:14]=[CH:15][C:16]=2[CH2:17][CH2:18]1