HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-amino-1H-indazol-1-yl)benzoate → Ethyl 3-(4-{[4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-1h-indazol-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-amino-1H-indazol-1-yl)benzoate | HCID 57615935 | — |
| Reactant | 7-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran | HCID 57775518 | — |
| Product | Ethyl 3-(4-{[4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-1h-indazol-1-yl)benzoate | HCID 57615954 | — |
Reaction Steps
Prepared similarly to Example 1 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and ethyl 3-(4-amino-1H-indazol-1-yl)benzoate (Intermediate 6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093281B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-12a0db22f6354e5fbec43fc61714b8a3 |
| Source note | uspto-grants-2012_01 |