2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

HRID 418801Notes

Reaction equation

HRID 418801 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][CH3:20])=[C:6]([C:8]([CH3:18])([CH3:17])[CH2:9][C:10]2([C:13]([F:16])([F:15])[F:14])[CH2:12][O:11]2)[CH:7]=1.[CH3:21][C:22]1[CH:23]=[C:24]([NH2:37])[C:25]2[CH:26]=[N:27][N:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:29]=2[CH:30]=1>>[F:14][C:13]([F:16])([F:15])[C:10]([CH2:12][NH:37][C:24]1[CH:23]=[C:22]([CH3:21])[CH:30]=[C:29]2[C:25]=1[CH:26]=[N:27][N:28]2[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)([OH:11])[CH2:9][C:8]([C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[O:19][CH3:20])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 160992392-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxiraneHCID 249380596-Methyl-1-phenyl-1H-indazol-4-amine2×

Product 1

HCID 119925191,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

Procedure

Prepared similarly to Example 14 from racemic 2-{2-[5-fluoro-2-(methyloxy)phenyl]-2-methylpropyl}-2-(trifluoromethyl)oxirane (which may be prepared according to WO 04/063163) and 6-methyl-1-phenyl-1H-indazol-4-amine (Intermediate 10).

Sources & evidence

ORD record
ord-be303380788243c6aee19876c15555a4
Source dataset
uspto-grants-2012_01
Patent number
US08093281B2

Reaction notes

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