2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

Participants

Role	Name	HCID	Charge
Reactant	2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane	HCID 16099239	—
Reactant	6-Methyl-1-phenyl-1H-indazol-4-amine	HCID 24938059	—
Product	1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol	HCID 11992519	—

Reaction Steps

Prepared similarly to Example 14 from racemic 2-{2-[5-fluoro-2-(methyloxy)phenyl]-2-methylpropyl}-2-(trifluoromethyl)oxirane (which may be prepared according to WO 04/063163) and 6-methyl-1-phenyl-1H-indazol-4-amine (Intermediate 10).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08093281B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-be303380788243c6aee19876c15555a4
Source note	uspto-grants-2012_01