反应详情

温度

110 °C

In a 50 mL round-bottomed flask fitted with condenser and magnetic stirrer were placed 5,7-Difluoro-2-(4-methoxyphenyl)-4H-chromen-4-one (0.425 g, 1.47 mmol), hydroiodic acid (10 mL) and acetic acid (5 mL). The reaction mixture was heated 110° C. for 4 h. The reaction mixture was cooled to room temperature and diluted with water. The precipitate was filtered off, washed with water and dried to give the title compound (220 mg, 54%). Selected data for the title compound: MS (ES) m/z: 275.10 (M+1); 19F-NMR (DMSO-d6): δ −106.2, −113.4.

1. customIn a 50 mL round-bottomed flask fitted with condenser and magnetic stirrer
2. temperatureThe reaction mixture was cooled to room temperature
3. filtrationThe precipitate was filtered off
4. washwashed with water
5. customdried