反应详情

温度

60 °C

HCl (0.4 mL, 2 N) was added to 4-isoquinolin-3-yl-phenol (0.044 g, 0.2 mmol) and the solution was heated at 60° C. for 10 min, resulting in a yellow solid. The reaction mixture was evaporated to dryness to give 4-(isoquinolin-3-yl)phenol hydrochloride (0.45 g, 77%). MS (ES) m/z: 222.96 (M+1), 221.95 (M); 13C-NMR (DMSO-d6): δ 180.2, 149.9, 138.8, 130.0, 129.6, 129.5, 127.8, 126.7, 116.7.

1. customresulting in a yellow solid
2. customThe reaction mixture was evaporated to dryness