Hydrochloric Acid → HCID 57942381, compound

HRID 419004Notes

Reaction equation

HRID 419004 reaction equation
C[O:2][C:3]([C:5]1[C:10]([NH:11][S:12]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([C:22]([F:25])([F:24])[F:23])[CH:16]=2)(=[O:14])=[O:13])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4].[OH-].[Na+].Cl>CO>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([S:12]([NH:11][C:10]2[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[CH:8][N:9]=2)(=[O:14])=[O:13])=[CH:16][C:17]=1[C:22]([F:23])([F:24])[F:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57942622HCID 57942622, compound

Product 1

HCID 57942381HCID 57942381, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyrazine-2-carboxylic acid methyl ester (60 mg), 3 mL of 2N NaOH and 3 mL of methanol was stirred at room temperature overnight. To the reaction mixture was added slowly 2M HCl until white solid precipitated. Filtration followed by vacuum drying afforded 3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyrazine-2-carboxylic acid as a white solid. MS: (M+H)/z=382.0.

Workup

  1. customprecipitated
  2. filtrationFiltration
  3. customdrying

Sources & evidence

ORD record
ord-76cb96106acc4f9f9a84b460c49dd963
Source dataset
uspto-grants-2012_01
Patent number
US08093247B2

Reaction notes

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