2-Chlorobenzaldehyde → (3-Amino-5-chloro-pyridin-2-yl)-(2-chloro-phenyl)-methanone

HRID 419046Notes

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Cl:10][C:11]1[CH:12]=[C:13]([N+:18]([O-])=O)[C:14](I)=[N:15][CH:16]=1>>[NH2:18][C:13]1[C:14]([C:4]([C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[Cl:1])=[O:5])=[N:15][CH:16]=[C:11]([Cl:10])[CH:12]=1

Participants

Reactant 2

HCID 69962-Chlorobenzaldehyde

HCID 579421085-Chloro-2-iodo-3-nitropyridine

Product 1

HCID 57942272(3-Amino-5-chloro-pyridin-2-yl)-(2-chloro-phenyl)-methanone

Procedure

(3-Amino-5-chloro-pyridin-2-yl)-(2-chloro-phenyl)-methanone was prepared from 2-chlorobenzaldehyde and 5-chloro-2-iodo-3-nitro-pyridine in three steps according to the general procedure for synthesis of 3-Amino-5-chloro-pyridin-2-yl aryl ketones. MS m/z: 267.0 (M+H).

Sources & evidence

ORD record: ord-2f4dec29713f4354a018e4ec50f3c7ac
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08093247B2

Reaction notes

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