1-(2-Iodo-5-isopropoxy-4-methoxyphenyl)ethanol → 2'-Iodo-5'-isopropoxy-4'-methoxyacetophenone

HRID 41921Notes

Reaction equation

HRID 41921 reaction equation
[I:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[CH:14]([OH:16])[CH3:15]>C(OCC)(=O)C.CCCCCC>[I:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[C:14](=[O:16])[CH3:15]

Participants

3

Reactant 1

HCID 667610301-(2-Iodo-5-isopropoxy-4-methoxyphenyl)ethanol

Product 1

HCID 667611172'-Iodo-5'-isopropoxy-4'-methoxyacetophenone

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Concentration of fraction B (Rf 0.6 in 1:1 v/v ethyl acetate/hexane) afforded the starting alcohol 6 (200 mg, 19% recovery) as a pale-yellow oil that was identical, as judged by 1H NMR spectroscopic analysis, with authentic material.

Sources & evidence

ORD record
ord-3f9e0455cb2c4997a7de0f7bd264406a
Source dataset
uspto-grants-2013_09
Patent number
US08536157B2

Reaction notes

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