2'-Iodo-5'-isopropoxy-4'-methoxypropiophenone → 5'-Hydroxy-2'-iodo-4'-methoxypropiophenone

HRID 41925Notes

Reaction equation

HRID 41925 reaction equation
[I:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10]C(C)C)=[CH:4][C:3]=1[C:14](=[O:17])[CH2:15][CH3:16]>C(OCC)(=O)C.CCCCCC>[OH:10][C:5]1[C:6]([O:8][CH3:9])=[CH:7][C:2]([I:1])=[C:3]([C:14](=[O:17])[CH2:15][CH3:16])[CH:4]=1

Participants

3

Reactant 1

HCID 667610452'-Iodo-5'-isopropoxy-4'-methoxypropiophenone

Product 1

HCID 667609615'-Hydroxy-2'-iodo-4'-methoxypropiophenone

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Concentration of fraction B (Rf 0.7 in 1:1 v/v ethyl acetate/hexane) afforded the starting ether 11 (98 mg, 21% recovery) as a pale-yellow oil that was identical, as judged by 1H NMR spectroscopic analysis, with authentic material.

Sources & evidence

ORD record
ord-4ae90d36c96c48969af44e062cb22feb
Source dataset
uspto-grants-2013_09
Patent number
US08536157B2

Reaction notes

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