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HRID419279

反应详情

EQUATION

反应方程式

HRID 419279 反应方程式

REACTANTS

反应物

3
5-Bromo-2-chloroanisole 分子结构式
HCID2769567

5-Bromo-2-chloroanisole

C7H6BrClO

tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate 分子结构式
HCID51072194

tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate

C15H25NO3

Butyllithium 分子结构式
HCID178418339

Butyllithium

C4H9Li

PRODUCTS

产物

1
9-(4-Chloro-3-methoxyphenyl)-3-azaspiro[5.5]undec-8-ene 分子结构式
HCID16006432

9-(4-Chloro-3-methoxyphenyl)-3-azaspiro[5.5]undec-8-ene

C17H22ClNO

AUXILIARIES

试剂、催化剂与溶剂

1
Tetrahydrofuran 分子结构式
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

Was prepared according to method A with the following variation: A solution of 5-bromo-2-chloroanisol (1.26 g, 5.7 mmol) in THF (7 mL) was added drop-wise to a solution of n-BuLi (1.6 M in hexanes (3.8 mL, 6.1 mmol)) at −78° C. and stirred for 30 min. A solution of 9-oxo-3-aza-spiro[5.5]undecane-3-carboxylic acid tert-butyl ester (475 mg, 1.78 mmol) in THF (7 mL) was added. The mixture was stirred for 1 h. White solid. Mp. 182-185° C.

WORKUP

后处理

  1. customWas prepared
  2. stirringThe mixture was stirred for 1 h