Tetrahydrofuran → (Benzo[c][1,2,5]oxadiazol-5-yl)methoxyphthalimide

Participants

Reaction Steps

5-(Bromomethyl)benzo[c][1,2,5]oxadiazole (0.441 g, 2.07 mmol) was added to a solution of N-hydroxyphthalimide (0.336 g, 2.06 mmol) in dry tetrahydrofuran (15 ml). N,N-Diisopropylethylamine (0.519 g, 4.02 mmol) was added and the solution was stirred at reflux under nitrogen for 23 h and cooled to room temperature. The suspension was concentrated in vacuo to a pale beige solid. This was diluted with water and filtered. The residue was washed with plenty of water and dried under vacuum to give (benzo[c][1,2,5]oxadiazol-5-yl)methoxyphthalimide (0.571 g, 94%).

Provenance & Evidence