反应详情

5-(Bromomethyl)benzo[c][1,2,5]oxadiazole (0.441 g, 2.07 mmol) was added to a solution of N-hydroxyphthalimide (0.336 g, 2.06 mmol) in dry tetrahydrofuran (15 ml). N,N-Diisopropylethylamine (0.519 g, 4.02 mmol) was added and the solution was stirred at reflux under nitrogen for 23 h and cooled to room temperature. The suspension was concentrated in vacuo to a pale beige solid. This was diluted with water and filtered. The residue was washed with plenty of water and dried under vacuum to give (benzo[c][1,2,5]oxadiazol-5-yl)methoxyphthalimide (0.571 g, 94%).

1. temperatureat reflux under nitrogen for 23 h
2. concentrationThe suspension was concentrated in vacuo to a pale beige solid
3. additionThis was diluted with water
4. filtrationfiltered
5. washThe residue was washed with plenty of water
6. customdried under vacuum