Bromine → HCID 57751902, compound

HRID 419693Notes

Reaction equation

HRID 419693 reaction equation
[Br:1]Br.[CH3:3][CH2:4][C:5]([C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:8]=1[F:17])=[O:6]>ClCCl>[Br:1][CH:4]([CH3:3])[C:5]([C:7]1[CH:12]=[C:11]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:9][C:8]=1[F:17])=[O:6]

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 6056751-[2-Fluoro-5-(trifluoromethyl)phenyl]propan-1-one

Product 1

HCID 57751902HCID 57751902, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Slowly add a solution of bromine (3.34 g, 0.95 equiv) in dichloromethane (80.00 mL) to a solution of 2-fluoro-5-(trifluoromethyl)propiophenone (5 g, 22.03 mmol) in dichloromethane (80 mL) is with stirring so that the brown color of bromine just disappears. Wash the reaction mixture with saturated NaHCO3, dry over Na2SO4 and concentrate to provide 6.22 g of crude material.

Workup

  1. washWash the reaction mixture with saturated NaHCO3
  2. dry with materialdry over Na2SO4
  3. concentrationconcentrate

Sources & evidence

ORD record
ord-2f2d6feb4c63485c85b6a659bff6316f
Source dataset
uspto-grants-2012_01
Patent number
US08093383B2

Reaction notes

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