HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → HCID 57751902, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-[2-Fluoro-5-(trifluoromethyl)phenyl]propan-1-one | HCID 605675 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57751902 | HCID 57751902 | 99.5% |
Reaction Steps
Slowly add a solution of bromine (3.34 g, 0.95 equiv) in dichloromethane (80.00 mL) to a solution of 2-fluoro-5-(trifluoromethyl)propiophenone (5 g, 22.03 mmol) in dichloromethane (80 mL) is with stirring so that the brown color of bromine just disappears. Wash the reaction mixture with saturated NaHCO3, dry over Na2SO4 and concentrate to provide 6.22 g of crude material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093383B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-2f2d6feb4c63485c85b6a659bff6316f |
| Source note | uspto-grants-2012_01 |