反应详情

Suspend 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine (250 mg, 0.80 mmol) in methanol (20 mL) and add hydrogen chloride (2 M in diethyl ether, 0.798 mL, 0.80 mmol). Stir at room temperature for 30 min. Concentrate the mixture in vacuo, and add water (15 mL) and acetonitrile (5 mL). Freeze-dry the mixture to afford an off-white solid. Dry the solid in vacuo at 100° C. for 2 h to afford 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine hydrochloride as an off-white solid (220 mg, 79%).

1. concentrationConcentrate the mixture in vacuo
2. additionadd water (15 mL) and acetonitrile (5 mL)
3. customFreeze-dry the mixture
4. customto afford an off-white solid
5. customDry the solid in vacuo at 100° C. for 2 h