反应详情

Dissolve 1-benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride (17.47 g 1.00 equiv; 65 mmoles) in 2M ammonia in methanol (˜350 mL). Saturate with ammonia gas for 15 min. Stir for 18 hours and evaporate. Co-evaporate with dry methanol. Dry under high vacuum to give 18.29 g (63.03 mmol, 97%) of 1-benzyl-piperidine-4-carboxamidine dihydrochloride as a light yellow solid.

1. concentrationSaturate with ammonia gas for 15 min
2. customevaporate
3. customCo-evaporate with dry methanol
4. customDry under high vacuum