HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-Benzyl-piperidine-4-carboxamidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride | HCID 66650058 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Benzyl-piperidine-4-carboxamidine dihydrochloride | HCID 66649853 | 97% |
Reaction Steps
Dissolve 1-benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride (17.47 g 1.00 equiv; 65 mmoles) in 2M ammonia in methanol (˜350 mL). Saturate with ammonia gas for 15 min. Stir for 18 hours and evaporate. Co-evaporate with dry methanol. Dry under high vacuum to give 18.29 g (63.03 mmol, 97%) of 1-benzyl-piperidine-4-carboxamidine dihydrochloride as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093383B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-e0d400d3d8724e68bc1210edb7eb3270 |
| Source note | uspto-grants-2012_01 |