HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 66649810, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 66650099 | HCID 66650099 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66649810 | HCID 66649810 | 103.5% |
Reaction Steps
Add hydrogen chloride (4 M in 1,4-dioxane, 5 mL, 20 mmol) to a solution of tert-5 butyl 4-(1-methyl-4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (400 mg, 1.10 mmol) in CH2Cl2 (10 mL) at 0° C. under nitrogen and stir for 2 h. Concentrate the mixture in vacuo to provide 4-(1-methyl-4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine dihydrochloride (435 mg, >99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093383B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-7e0879d4f6c04b45b965d09114c437b0 |
| Source note | uspto-grants-2012_01 |