Hydrochloric Acid → HCID 66649810, compound

HRID 419715Notes

Reaction equation

HRID 419715 reaction equation
[ClH:1].[CH3:2][N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:5]=[C:4]1[CH:18]1[CH2:23][CH2:22][N:21](C(OCCCC)=O)[CH2:20][CH2:19]1>C(Cl)Cl>[ClH:1].[ClH:1].[CH3:2][N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=2)[N:5]=[C:4]1[CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66650099HCID 66650099, compound

Product 1

HCID 66649810HCID 66649810, compoundYield 103.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add hydrogen chloride (4 M in 1,4-dioxane, 5 mL, 20 mmol) to a solution of tert-5 butyl 4-(1-methyl-4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (400 mg, 1.10 mmol) in CH2Cl2 (10 mL) at 0° C. under nitrogen and stir for 2 h. Concentrate the mixture in vacuo to provide 4-(1-methyl-4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine dihydrochloride (435 mg, >99%).

Workup

  1. concentrationConcentrate the mixture in vacuo

Sources & evidence

ORD record
ord-7e0879d4f6c04b45b965d09114c437b0
Source dataset
uspto-grants-2012_01
Patent number
US08093383B2

Reaction notes

Loading…