HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178478946, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178451792 | HCID 178451792 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178478946 | HCID 178478946 | 90% |
Reaction Steps
Add hydrogen chloride (2 mL, 12 M aqueous) to a solution of 4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (275 mg; 665.19 μmoles) in methanol (10 mL). Stir the mixture at room temperature overnight, and then concentrate and dry to offer 210 mg (90% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08093383B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-3b323ed5a0514541a229e37ea29ca1e4 |
| Source note | uspto-grants-2012_01 |