Hydrochloric Acid → HCID 178478946, compound

HRID 419717Notes

Reaction equation

HRID 419717 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[NH:16][CH:17]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:21]=3)[N:19]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[F:26][C:23]1[CH:24]=[CH:25][C:20]([C:18]2[N:19]=[C:15]([CH:12]3[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]3)[NH:16][CH:17]=2)=[CH:21][C:22]=1[C:27]([F:28])([F:29])[F:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451792HCID 178451792, compound

Product 1

HCID 178478946HCID 178478946, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add hydrogen chloride (2 mL, 12 M aqueous) to a solution of 4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (275 mg; 665.19 μmoles) in methanol (10 mL). Stir the mixture at room temperature overnight, and then concentrate and dry to offer 210 mg (90% yield) of the title compound.

Workup

  1. concentrationconcentrate
  2. customdry

Sources & evidence

ORD record
ord-3b323ed5a0514541a229e37ea29ca1e4
Source dataset
uspto-grants-2012_01
Patent number
US08093383B2

Reaction notes

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