Sodium Hydroxide → HCID 66651500, compound

HRID 419764Notes

Reaction equation

HRID 419764 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[S:18])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1.[OH-].[Na+]>C(O)C.O>[Br:1][C:2]1[C:3]2[N:8]=[C:9]([C:10]3[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=3)[S:18][C:4]=2[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 11537080HCID 11537080, compound

Product 1

HCID 66651500HCID 66651500, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Conditions

Temperature
85 °C

Procedure

To a solution of EXAMPLE 1B (7.1 g) in ethanol (26 mL) was added 30% sodium hydroxide (17.63 mL) and the mixture was stirred for 5 minutes. Water (35 mL) was added and 4 mL aliquots of the mixture were added at 1-minute intervals to a heated (85° C.) solution of potassium ferricyanide(III) (29 g) in water (260 mL). The mixture was maintained at 85° C. for 30 minutes and cooled. The precipitate was collected, washed with water and dried to afford the title compound.

Workup

  1. addition4 mL aliquots of the mixture were added at 1-minute intervals to
  2. temperaturecooled
  3. customThe precipitate was collected
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-b1c93e8a17a14a46a1c9a6dbf1eea56c
Source dataset
uspto-grants-2012_01
Patent number
US08093396B2

Reaction notes

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