反应详情

温度

110 °C

To a solution of N-(6-phenyl-5-(trifluoromethyl)pyridin-3-yl)acetamide (1.68 mmol, 0.280 g) in ethanol (6 ml), 2N aqueous NaOH (5 ml) was added. The mixture was heated at 110° C. for 3 hours. The solvent was removed, the pH was set at 8 and extracted with CHCl3. The solvent was removed to afford 0.394 g (98% of yield) of the expected product.

1. customThe solvent was removed
2. extractionextracted with CHCl3
3. customThe solvent was removed
4. customto afford