N-(6-phenyl-5-(trifluoromethyl)pyridin-3-yl)acetamide → HCID 58415894, compound

HRID 41977Notes

Reaction equation

HRID 41977 reaction equation
[C:1]1([C:7]2[N:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][C:8]=2[C:17]([F:20])([F:19])[F:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[OH-].[Na+]>[C:1]1([C:7]2[N:12]=[CH:11][C:10]([NH2:13])=[CH:9][C:8]=2[C:17]([F:20])([F:18])[F:19])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 67395105N-(6-phenyl-5-(trifluoromethyl)pyridin-3-yl)acetamide

Product 1

HCID 58415894HCID 58415894, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of N-(6-phenyl-5-(trifluoromethyl)pyridin-3-yl)acetamide (1.68 mmol, 0.280 g) in ethanol (6 ml), 2N aqueous NaOH (5 ml) was added. The mixture was heated at 110° C. for 3 hours. The solvent was removed, the pH was set at 8 and extracted with CHCl3. The solvent was removed to afford 0.394 g (98% of yield) of the expected product.

Workup

  1. customThe solvent was removed
  2. extractionextracted with CHCl3
  3. customThe solvent was removed
  4. customto afford

Sources & evidence

ORD record
ord-29505630d48342969042ce39b02f1f8e
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Reaction notes

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